解:由题意可得$\frac {M}{a+1}=\frac {a^2}{a(a+1)}=\frac {a}{a+1},$
则$M=a,$
那么$\frac {a}{a+1}-\frac {1}{a^2+a}$
$=\frac {a^2}{a(a+1)}-\frac {1}{a(a+1)}$
$=\frac {a^2-1}{a(a+1)}$
$=\frac {(a+1)(a-1)}{a(a+1)}$
$=\frac {a-1}{a},$
当$a=100$时,
原式$=\frac {100-1}{100}=\frac {99}{100}.$